Outlive: The Science and Art of Longevity Hardcover – March 28, 2023

The book "outlives" describes the ultimate goal of medicine. The next generation of modern medicine is called Medicine 3.0. It focuses on the well-being of a patient and the prevention rather than treatment. It will make us healthy, happy, strong, and able to live longer without disease. The concept is that metabolic dysfunction causes a lot of chronic diseases that increase mortality in developed nations.Therefore, the priority of Medicine 3.0 is to address metabolic issues rooted in many chronic diseases. We should pay attention to the five domains mainly. They are diet, exercise, sleep, emotional health, and exogenous. As a doctor, I feel sympathy with the concept of the book. The book is sophisticated and supported by a lot of evidence. I want to recommend every healthcare worker to read the book.

Great book. Already applying some of the recommendations. It’s a little too much science jargon in some sections for me but think others might appreciate the explanations if they can follow. Peter does try to simplify some of the more academic parts but there is also enough practical advice to still get a lot out of the book even if some of the explanations go over your head.

The main theme of “Outlive” is not to explore exotic scientific discoveries or secrets of longevity. It is rather to help you to plan and implement the high-leverage interventions to lower the risks of the diseases that will likely prevent most of us from having better and healthy life at the later (or even now) stage of life. We all have a tendency to be attracted to and seek a silver bullet to cure every disease and reverse aging. Our inclination towards easy instant solutions might be reflected in the popularity of “anti-aging” supplements (e.g. NMN) and other mythic do-this/don’t-do-this books. Instead, Petter Attia has proposed a highly proactive and comprehensive strategy to prevent the major diseases that are dominant causes of death in developed countries: heart diseases, cancer, Alzheimer’s disease, and type-2 diabetes. He calls such a radically preventive approach Medicine 3.0 as opposed to the traditional and currently mainstream medicine, which focuses on curing the diseases once you get them or, more ironically speaking, waits for you to become ill and then tries to cure them, often ending up prolonging the lifespan at the expense of quality of life.While this notion does not sound groundbreaking at all, I think this is the catch. While modern medicine has undoubtedly made significant progress in understanding these diseases of aging (heart diseases, cancer, dementia, and type-2 diabetes), it has failed to eradicate them. On the contrary, these diseases are becoming more prevalent and still killing most of us. Given that there is no magic pill for longevity neither, it is the most realistic approach towards longevity to de-risk these major diseases by addressing all the potential root causes without waiting for these diseases to come to you. This will certainly extend the health span, where you keep on enjoying the quality of life at the same level as you do when you are young. With Medicine 2.0, which focuses on prolonging life span, our quality of life is meant to slowly decay as we age, and so do our physical, cognitive, and emotional states. You might not be able to play football during the weekend or have no mental energy to start new projects in your 60s as you do in your 30s. Medicine 3.0 strives to square the decay curve by paying as much attention to health span as it does to life span. So Outlive is like a manifesto to be a kick-ass centenarian.Another important feature of the Peter Attia’s Medicine 3.0 is to seek patients to be captains of their own health, not passive passengers. Preventive medicine requires you to do more than just take medication: change behaviors, find what works for you, organize your priorities and time schedule, and so on. Thus, it does not give you a simple do-this and not-do-this list. If you are looking for such quick tips, you will be highly disappointed.Peter Attia first thoroughly explores the current scientific understanding of centenarians, hunger (and its effect on health), metabolic health, and possible causes of diseases of aging (heart diseases, cancer, and Alzheimer’s disease). Informed of these scientific findings, he then draws the framework of principles so that you can plan the concrete actions that work for you. In this regard, he explores again the potency of four tactical (action) domains: exercise (aerobic efficiency, aerobic capacity, strength, and stability), nutrition, sleep, and emotional health. Again, the book does not provide a list of actions or interventions. However, you will have a better understanding of what should be done and what steps you can take to incorporate these tactics into your daily life. In the end, every person is different and needs different actions. So it is not possible to design the perfect plan that fits for everyone. You must do it by yourself.As a long-time listener of his podcast (Drive), in which he covers almost every aspect of health with top researchers from each domain, I am astonished at his work of compiling and condensing such broad and deep topics into one enjoyable book. Each topic can be easily a stand-alone book at its minimum. Thus, if you feel unsatisfied with the depth of the content of the book, you can listen to his podcast or go through the scientific journals to deep dive into the ocean of scientific expeditions for longevity.Before hitting the road toward longevity, it is worthwhile to ask ourselves why we want to live long(er). In the end, if life sucks, living longer sounds completely pointless. The answers to this question are different for each person. In the last chapter of this book, Peter wrote his own painful experience on this question, and his work in progress not to ignore the emotional health.Overall, I highly recommend Outlive to everyone, including all of my friends and family. Yes, this is exactly part of my longevity tactics as well.

Very informative ..recommended

I saw Peter Attia's Ted Talk about diabetes 10 years ago. For the time, it challenged conventional wisdom about diabetes and obesity. It changed my life for the better and I thank him tremendously.Here, in his book there was no "mind-blown" moment. The message to me, was that conventional wisdom is correct, with one caveat. Yes, eat well, exercise, and take care of your mental health, but do it in a way that your body responds optimally. He provides the targets but the best WAY requires some self-analysis.I recommend this book for the latest insight into longevity. I think most people will find some valuable gems in this book.

日本ではなかなか出会えない医者の気概、考え方です。このようや医者が増えたらどんなに素晴らしいことか。他人に望むのは簡単なので多くの、医者ではない私たちが読み、学ぶことが大切。

I am about 3 chapters into this book and compared to other books in this field I like his style and unique realistic approach to Medicine 3.0 as he calls it.Highly recommended, I read a few pages every night

The pages were scratched, some seemed like they had gotten wet and dried again. The cover of the book was very beat up.