The Total IGFBP-3 ELISA kit, a quantitative two-step sandwich immunoassay, provides materials for the measurement of Total IGFBP-3 in human serum and other biological fluids. The Ansh Labs Total IGFBP-3 Assay uses an acidification and neutralization method to dissociate IGFBP-3 from all the binding subunits. Total IGFBP-3 levels are quantified in the extracted samples using a highly sensitive and specific total IGFBP-3 ELISA. Low IGFBP-3 and IGF-1 levels are observed in GH deficiency or GH resistance, also epidemiologic studies suggest that low IGFBP-3 is associated with greater risk of aggressive, metastatic prostate cancers. The elevated serum IGFBP-3 and IGF-1 levels indicate a sustained overproduction of GH, or excessive rhGH therapy. Both conditions are associated with generalized organomegaly, hypertension, diabetes, cardiomyopathy, osteoarthritis, and diminished longevity.Analytical measureable range of 0.10 - 10 ng/mL allows for studies in a variety of physiological states. Sensitive to 0.065 ng/mL. Total 3.5 hour incubation at room temperature. Long shelf life of 24 months.For Research Use Only within the United States. Reference the directional insert on the company's website for more updated specifications as they may have changed.Ansh Labs, located just south of Houston Texas, is an FDA registered manufacturer of diagnostic test kits, antibodies, antigens, and proteins. Our scientists are experts in immunoassay development and have developed some of the most challenging hormone assays helping to advance research and clinical diagnostics in reproductive function, growth disorders, metabolism, and more.
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