Is it possible to use two sets of outputs - as in run the XLR outputs to the house PA and run the line outs to a keyboard amp so band can monitor?

Yes, the input signal, regardless of connector used, is present on all outputs. http://artproaudio.com/downloads/specsheets/ss_dti.pdf

does it have a ground "lift" option, switchable?

No "BUT" all outputs are ground isolated from the chassis so a "lift" switch is not necessary when using this.

I want to use my studio monitors with my Macbook Pro. What cable do I need to use to plug this into my laptop?

Hi Jason,I would use an 1/8" to XLR Male Y cable like this:http://www.amazon.com/Hosa-CYX-403M-Stereo-Breakout-Cable/dp/B000068OEP/ref=sr_1_9?m=A3QYKZ7LXW9O3&s=merchant-items&ie=UTF8&qid=1448889739&sr=1-9&keywords=hosa+1%2F8+to+xlrIf this was helpful, please consider purchasing from us. We have them both in stock and ready to ship. - Pixel Pro Audio

ASIN	B0009GUOQA
Best Sellers Rank	#66,388 in Industrial & Scientific ( See Top 100 in Industrial & Scientific ) #2 in Audio Transformers
Date First Available	April 13, 2004
Department	Professional Audio
Is Discontinued By Manufacturer	No
Item Weight	12 ounces
Item model number	DTI
Manufacturer	ART
Product Dimensions	11 x 3 x 7 inches
UPC	840402016380

ART DTI Dual Transformer Isolator Hum Eliminator

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