How often do they need to be changed?

These types of media don’t need to be changed, there’s bacteria on it that helps lower nitrites and nitrates.

Do these need to be cleaned or changed? Or do I just leave them alone?

As long as you place them after mechanical filtration, they do not need to be cleaned.

Is it safe to put these directly in my tank?

hello yes you can use the Marine pure Gems directly in your tank , if you want to get some help you can add bacteria in liquid directly on your gems to accelerate their growth.

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CerMedia MarinePure Marine Pure Biofilter Media Gems - 90g, Tan (905002)

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