Will an epipen fit in this?

Yes, I believe it will. I must tell you though, this product does NOT hold up under extreme heat. Also, as far as I know epipens are NOT refrigerated! Don't know if I helped. I would NOT purchase this product again.

What size would be good for two Auvi-Q (for food allergies) injectors?

the individual one is too small - go with the double one. these are great i travel all over the usa with mine. i carry my diabetic pens in mine

Will a humulin r u-500 (concentrated) kwikpen 500 unit/ml (3 ml) fit into one of these?

Should be plenty of room plus a couple caps

I work landscaping and need something to keep dust and debris from gumming up the dial on my kwik pen. Does this have a flap to cover the pen?

Yes, it has an inner envelope that you soak in water to activitate the cooling gel. The outer envelope, has a flap that velcros shut, good product,

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❄️💼 Cool confidence, wherever life takes you.

POWER OUTAGE PROOF - Keeps insulin safe during prolonged outages—your emergency kit’s new MVP.
STAY COOL STAY FREE - No ice packs or refrigeration needed—just soak and go for 48+ hours of reliable cooling.
REUSABLE ECO FRIENDLY - Sustainable cooling that’s ready whenever you are—just re-soak and reuse endlessly.
PERFECT FIT FOR YOUR PEN - Designed for standard injection pens with a 2.5"x7" interior—adaptable for chunky pens with shorter soak.
TRAVEL LIGHT TRAVEL SMART - Slim, lightweight wallet fits easily in your bag or pocket for on-the-go peace of mind.

The Frio Insulin Cooling Case is a reusable, water-activated evaporative cooler that keeps insulin and other temperature-sensitive medications below 78°F for over 48 hours without ice or refrigeration. Compact and lightweight, it’s ideal for travel, camping, and emergency preparedness, offering freedom and peace of mind by protecting your medication through power outages and on-the-go adventures.